Clinical trials focused on vitamin E were not successful to lower cholesterol. Das et al 2012 assessed the LDL reducing role of isomers of vitamin E, the tocotrienols. Rabbits were submitted to cholesterol-rich diet supplemented with tocotrienols. [1]
The authors report that left ventricular function including aortic flow, the developed pressure, and the myocardial infarct size exhibited significantly improved recovery with tocotrienol-γ and -α, but not with tocotrienol-δ.